Our daughter works for a multinational company. Since she took the job she has always worked from home.
Across the world though this seems to be causing a problem. Some employees, also working from home, report that they are lonely, depressed and even suicidal.
The company now has set aside time to combat this, by getting colleagues to chat to one person on line (using zoom or facetime or whatever). Then after five minutes they stop and move to chat to another colleague for five minutes.
Human beings are social animals. We aren't meant to lock ourselves away from other human contact, it's not good for us.